Shvetz V I, Krasnopol'skiĭ Iu M, Kaplun A P, Stepanov A E
Vopr Med Khim. 1997 Sep-Oct;43(5):416-24.
The paper summarizes own results of studies on phospholipids and glycolipids from natural biological sources. New approaches for synthesis of inositol-containing sphingophospholipids, glycophosphatidylinositols, semisynthetic synthesis of phosphoglycerols have been introduced. New industrial method of phosphjatidylcholine isolation and production of number of lipid preparations were developed. Incorporation of DOPA into liposomes increases efficacy of its action in the medication of MPTP-induced parkinsonism in mice.
本文总结了从天然生物来源中提取磷脂和糖脂的研究成果。介绍了含肌醇鞘磷脂、糖基磷脂酰肌醇的合成新方法以及磷酸甘油的半合成方法。开发了磷脂酰胆碱分离的新工业方法以及多种脂质制剂的生产方法。将多巴掺入脂质体可提高其在治疗小鼠MPTP诱导的帕金森病中的疗效。