Paluszkiewicz P, Pawłowska-Wakowicz B, Karski J
Kliniki Chirurgii Urazowej Akademii Medycznej w Lublinie.
Wiad Lek. 1997;50 Suppl 1 Pt 1:82-6.
We analysed the nm23 protein expression in the selected group of 80 patients with sporadic colorectal cancer. nm23 protein was detected in cytoplasm with use of monoclonal anti nm23 antibody. Decreased expression of nm23 protein was found in 58/80 (72.5%) colorectal cancer samples. Positive reaction was found more often in the group A and B according to Dukes, than in the C and D. The difference was statistically significant at p < 0.05, and the occurrence was 75% vs. 15.63% respectively. We also found statistically significant difference in nm23 protein expression in well differentiated (G1) and poorly (G3) and intermediate (G2) differentiated. The positive reaction was observed in 85.71% in G1 group and 12.92% in G2 and G3 together. On the base of our study we suggest a usefulness of histochemical identification of nm23 protein expression in evaluation of metastatic potential of colorectal cancer.
我们分析了80例散发性结直肠癌患者的nm23蛋白表达情况。使用抗nm23单克隆抗体在细胞质中检测到nm23蛋白。在80例（72.5%）结直肠癌样本中发现nm23蛋白表达降低。根据Dukes分期，A组和B组的阳性反应比C组和D组更常见。差异具有统计学意义（p < 0.05），发生率分别为75%和15.63%。我们还发现，高分化（G1）、低分化（G3）和中分化（G2）的nm23蛋白表达存在统计学显著差异。G1组的阳性反应率为85.71%，G2组和G3组的阳性反应率合计为12.92%。基于我们的研究，我们认为nm23蛋白表达的组织化学鉴定在评估结直肠癌转移潜能方面具有实用性。
