Raman R K
J Cell Sci. 1976 May;20(3):497-512. doi: 10.1242/jcs.20.3.497.
Measurements on the chemotactic aggregation of the amoebae of the cellular slime mould Dictyostelium minutum are reported. With the aid of previous theoretical results, the observed patterns of early aggregation on 2- and 3-dimensional substrates are interpreted. There is no statistically significant difference in the patterns in the 2 cases. The results suggest that the simplest plausible chemotactic law for this system is the relative gradient law in which the response velocity of the amoebae is proportional to the relative acrasin gradient. The results also suggest that the differentiation of the founder cell, which initiates aggregation, occurs before all cells have acquired chemotactic sensitivity. A diffusible chemical may be involved in the development of the latter.
报道了对细胞黏菌微小盘基网柄菌变形虫趋化聚集的测量结果。借助先前的理论结果，对在二维和三维基质上早期聚集的观察模式进行了解释。这两种情况下的模式没有统计学上的显著差异。结果表明，该系统最简单合理的趋化定律是相对梯度定律，即变形虫的反应速度与相对聚集素梯度成正比。结果还表明，引发聚集的起始细胞的分化发生在所有细胞都获得趋化敏感性之前。一种可扩散的化学物质可能参与了后者的发育过程。
