Isaacs J D, Hines R S, Sopelak V M, Cowan B D
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216, USA.
J Assist Reprod Genet. 1997 Nov;14(10):551-3. doi: 10.1023/a:1022592715006.
Ovarian endometriomas have an uncertain impact on outcome following in vitro fertilization (IVF). Some authors describe a poor response to ovulation induction, and others observe decreased pregnancy success rates. Conversely, IVF outcomes similar to those of patients undergoing IVF for tubal-factor infertility have also been reported. To determine the impact of ovarian endometriomas on pregnancy success in our IVF program, we identified patients with endometriosis and compared outcomes that were stratified by the presence or absence of an endometrioma at the time of follicular aspiration.
One hundred eight patients with a diagnosis of endometriosis treated with IVF were identified, retrospectively. In this group, 24 patients completed 29 cycles in which an ovarian endometrioma was aspirated at the time of oocyte retrieval, and 84 patients without endometriomas completed 147 cycles. The cycles from these two groups were compared for differences in peak estradiol, number of mature follicles, number of oocytes, number of embryos transferred, and clinical pregnancies.
There were no significant differences between the two groups with respect to peak estradiol, mature follicles, number of oocytes, number of embryos transferred, or clinical pregnancies.
From this retrospective observational analysis it appears that aspiration of an endometrioma at the time of oocyte retrieval has no adverse effect on outcome. This information may prove helpful when faced with the decision to cancel an IVF treatment cycle in patients with this uncommon complication.
卵巢子宫内膜异位囊肿对体外受精（IVF）后的结局影响尚不确定。一些作者描述其对排卵诱导反应不佳，另一些作者则观察到妊娠成功率降低。相反，也有报道称其IVF结局与因输卵管因素不孕而接受IVF治疗的患者相似。为了确定卵巢子宫内膜异位囊肿对我们IVF项目中妊娠成功率的影响，我们识别了患有子宫内膜异位症的患者，并比较了在卵泡抽吸时存在或不存在子宫内膜异位囊肿分层后的结局。
回顾性识别了108例诊断为子宫内膜异位症并接受IVF治疗的患者。在该组中，24例患者完成了29个周期，这些周期在取卵时抽吸了卵巢子宫内膜异位囊肿，84例没有子宫内膜异位囊肿的患者完成了147个周期。比较这两组周期在雌二醇峰值、成熟卵泡数量、卵母细胞数量、移植胚胎数量和临床妊娠方面的差异。
两组在雌二醇峰值、成熟卵泡、卵母细胞数量、移植胚胎数量或临床妊娠方面无显著差异。
从这项回顾性观察分析来看，取卵时抽吸子宫内膜异位囊肿对结局没有不良影响。当面临取消患有这种罕见并发症患者的IVF治疗周期的决定时，该信息可能会有所帮助。
