辅助生殖后妊娠的围产期结局：一项病例对照研究。
Perinatal outcome of pregnancies after assisted reproduction: a case-control study.
作者信息
Dhont M, De Neubourg F, Van der Elst J, De Sutter P
机构信息
Department of Obstetrics and Gynecology, University Hospital, Ghent, Belgium.
出版信息
J Assist Reprod Genet. 1997 Nov;14(10):575-80. doi: 10.1023/a:1022576500894.
PURPOSE
A matched case-control study of all pregnancies obtained after either IVF or ICSI was conducted to investigate the perinatal outcome.
METHODS
Three hundred eleven singleton and 115 twin pregnancies obtained after assisted reproduction were studied. Controls were selected from a regional register and were matched for maternal age, parity, singleton or twin pregnancy, and date of delivery.
RESULTS
No significant difference was observed for gestational age at delivery, birth weight, incidence of congenital anomalies, and incidence of perinatal mortality between ART (singleton and twin) pregnancies and spontaneous controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies (52 vs 42%; P < 0.05) and needed more neonatal intensive care (47 vs 26%; P < 0.05).
CONCLUSIONS
From this case-control study it is concluded that the perinatal outcome of ART singleton pregnancies is not different from that in matched controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies and needed more neonatal intensive care.
目的
开展一项针对通过体外受精（IVF）或卵胞浆内单精子注射（ICSI）后获得的所有妊娠的配对病例对照研究，以调查围产期结局。
方法
对辅助生殖后获得的311例单胎妊娠和115例双胎妊娠进行了研究。对照组从地区登记册中选取，并在产妇年龄、产次、单胎或双胎妊娠以及分娩日期方面进行匹配。
结果
辅助生殖（单胎和双胎）妊娠与自然受孕对照组在分娩时的孕周、出生体重、先天性异常发生率和围产期死亡率方面未观察到显著差异。辅助生殖双胎妊娠的早产发生率高于对照妊娠（52%对42%；P<0.05），且需要更多的新生儿重症监护（47%对26%；P<0.05）。
结论
从该病例对照研究得出结论，辅助生殖单胎妊娠的围产期结局与匹配对照组无异。辅助生殖双胎妊娠的早产发生率高于对照妊娠，且需要更多的新生儿重症监护。
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