Igbokwe I O, Nwosu C O
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria.
J Comp Pathol. 1997 Oct;117(3):261-5. doi: 10.1016/s0021-9975(97)80020-5.
Isolates of Trypanosoma brucei and Trypanosoma congolense from the blood of cattle were used to infect growing rats. Despite the use of similar infective doses, T. brucei parasitaemia appeared earlier than T. congolense parasitaemia. After the same period of parasitaemia, the degrees of anaemia, splenomegaly and hepatomegaly were similar in both infections. The percentage decrease in packed cell volume was not correlated with splenic and hepatic weights. Neither infection significantly affected the weight gain of the rats. It was concluded that both organisms caused diseases of comparable severity and that the mere enlargement of the spleen and liver made no significant contribution to the development of the anaemia.
从牛血液中分离出的布氏锥虫和刚果锥虫菌株用于感染生长中的大鼠。尽管使用了相似的感染剂量，但布氏锥虫血症比刚果锥虫血症出现得更早。在相同的寄生虫血症期后，两种感染中贫血、脾肿大和肝肿大的程度相似。红细胞压积的降低百分比与脾脏和肝脏重量无关。两种感染均未显著影响大鼠的体重增加。得出的结论是，这两种生物体引起的疾病严重程度相当，脾脏和肝脏仅仅肿大对贫血的发展没有显著影响。
