Hirai N, Miura T, Moriyasu M, Ichimaru M, Nishiyama Y, Ogura K, Kato A
Kobe Pharmaceutical University, Hyogo, Japan.
Biol Pharm Bull. 1997 Dec;20(12):1271-3. doi: 10.1248/bpb.20.1271.
The cardiotonic effect of the rhizome of Polygonatum sibiricum was investigated in the left atria of rats. The methanol extract of the rhizome of Polygonatum sibiricum (OM) (1-7 mg/ml) concentration-dependently increased the developed tension of the left atrium. It also strongly inhibited cAMP phosphodiesterase. The increase cAMP level correlated the increase in left atrial contraction. On the other hand, OM did not inhibit Na+, K+-ATPase. The cardiotonic effect of OM was strongly inhibited by reserpine, a sympatholytic agent. Furthermore, OM-treated left atria inhibited the tension produced by propranolol, a beta adrenocepter antagonist. These findings suggested that the cardiotonic effect is due to stimulating beta adrenoceptors through activation of sympathetic nerves.
研究了黄精根茎对大鼠左心房的强心作用。黄精根茎甲醇提取物（OM）（1-7毫克/毫升）浓度依赖性地增加左心房的舒张张力。它还强烈抑制环磷酸腺苷磷酸二酯酶。环磷酸腺苷水平的升高与左心房收缩的增加相关。另一方面，OM不抑制钠钾ATP酶。利血平（一种交感神经阻滞剂）强烈抑制OM的强心作用。此外，经OM处理的左心房抑制了β肾上腺素能受体拮抗剂普萘洛尔产生的张力。这些发现表明，强心作用是由于通过激活交感神经刺激β肾上腺素能受体所致。
