Shoji N, Umeyama A, Takemoto T, Kajiwara A, Ohizumi Y
J Pharm Sci. 1986 Jun;75(6):612-3. doi: 10.1002/jps.2600750619.
The crude acetone extract of the fruits of Evodia rutaecarpa Bentham (Rutaceae) exhibited a positive inotropic effect on the guinea pig isolated left atria. The extract was subject to bioassay-directed fractionation to yield the powerful cardiotonic agent evodiamine.