Choi M G, Camilleri M, Burton D D, Zinsmeister A R, Forstrom L A, Nair K S
Mass Spectrometry Core Laboratory, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Am J Gastroenterol. 1998 Jan;93(1):92-8. doi: 10.1111/j.1572-0241.1998.092_c.x.
The accuracy of the 13C-octanoic acid breath test is enhanced by breath sampling over 6 h rather than 4 h, but this increases the cost of the test. Our aim was to validate a less costly but accurate sequence of breath sampling for measuring gastric emptying of solids.
We performed the 13C-octanoic acid breath test and tested its reproducibility relative to simultaneous scintigraphy in 30 healthy volunteers.
There was a significant but weak correlation between t1/2 measured by the two tests (rs = 0.54, p < 0.005), but not between the duration of the lag phase. The differences in the t1/2 measurements between the tests were different between subjects but were highly reproducible within subjects. Within- and between-subject variations of measurements of gastric emptying with the 13C-octanoic acid breath test were not significantly different from the variations observed with scintigraphy. A subset of 11 breath samples collected over 6 h (24 samples) predicted (r2 > 0.95) the variables characterizing the cumulative appearance of 13CO2 in breath; these samples were at 35, 50, 95, 110, 140, 155, 215, 245, 260, 290, and 335 min. The accuracy of this subset of sampling times was confirmed in a separate set of breath test samples over 6 h from the same 30 subjects.
The 13C-octanoic acid breath test for gastric emptying of solids is as reproducible as scintigraphy. A subset of 11 sampling times provides sufficient information to characterize the whole breath-test curve, but the sampling period should be extended to 6 h after dosing.
13C - 辛酸呼气试验通过6小时而非4小时的呼气采样可提高准确性，但这会增加测试成本。我们的目的是验证一种成本较低但准确的呼气采样序列，用于测量固体食物的胃排空。
我们对30名健康志愿者进行了13C - 辛酸呼气试验，并测试了其相对于同步闪烁扫描的可重复性。
两种测试所测得的t1/2之间存在显著但较弱的相关性（rs = 0.54，p < 0.005），但延迟期的持续时间之间无相关性。测试之间t1/2测量值的差异在不同受试者之间有所不同，但在同一受试者内具有高度可重复性。13C - 辛酸呼气试验测量胃排空的受试者内和受试者间变异与闪烁扫描观察到的变异无显著差异。在6小时内采集的11个呼气样本子集（共24个样本）预测（r2 > 0.95）了表征呼气中13CO2累积出现的变量；这些样本采集时间为35、50、95、110、140、155、215、245、260、290和335分钟。在来自相同30名受试者的另一组6小时呼气测试样本中证实了该采样时间子集的准确性。
用于固体食物胃排空的13C - 辛酸呼气试验与闪烁扫描具有同样的可重复性。11个采样时间的子集提供了足以表征整个呼气测试曲线的信息，但给药后采样期应延长至6小时。
