Wuestenberghs Fabien, Juge Mathilde, Melchior Chloé, Desprez Charlotte, Leroi Anne-Marie, Gourcerol Guillaume
Department of Gastroenterology and Hepatology, CHU UCL Namur, Godinne University Hospital, UCLouvain, Yvoir, Belgium.
Department of Physiology, Rouen University Hospital, Normandie University, Rouen, France.
J Neurogastroenterol Motil. 2019 Oct 30;25(4):534-543. doi: 10.5056/jnm19060.
BACKGROUND/AIMS: Association between symptoms, quality of life and gastric emptying in dyspepsia is inconsistent in the literature. The aim of our study is to investigate if gastric emptying is associated with specific symptoms and quality of life in dyspeptic patients.
We reviewed retrospectively gastric emptying measured by C-labelled octanoate breath testing for more than 6 hours in 198 consecutive patients with dyspepsia complaints. Gastrointestinal symptoms were assessed using a 5-points Likert scale and by a symptomatic composite score, whereas quality of life was measured by the GIQLI.
In our cohort, 90 patients (45%) had a delayed gastric emptying (half emptying time above 166 minutes when assessed over 6-8 hours). There was no difference in symptoms or quality of life between patients with or without delayed gastric emptying. However, patients with severely delayed gastric emptying (half emptying time above 200 minutes) had increased postprandial fullness ( = 0.012), abdominal pain ( = 0.026), bloating ( = 0.044), early satiety ( = 0.018), symptomatic composite score ( = 0.005), and a lower quality of life ( = 0.018). This association was no longer observed if the calculation of gastric emptying was limited to the first 4-hour samples.
There is no association between symptoms, quality of life and gastric emptying in an overall dyspeptic population. However, there is an association between symptoms, quality of life of delayed gastric emptying in the subgroup of patients with severely delayed gastric emptying. An 8-hour measurement of gastric emptying should be recommended.
背景/目的：消化不良患者的症状、生活质量与胃排空之间的关联在文献中并不一致。我们研究的目的是调查胃排空是否与消化不良患者的特定症状及生活质量相关。
我们回顾性分析了198例连续的有消化不良症状患者通过C标记辛酸呼气试验测量超过6小时的胃排空情况。胃肠道症状采用5级李克特量表及症状综合评分进行评估，而生活质量则通过胃肠道生活质量指数（GIQLI）来衡量。
在我们的队列中，90例患者（45%）胃排空延迟（6 - 8小时评估时半排空时间超过166分钟）。胃排空延迟和未延迟的患者在症状或生活质量方面没有差异。然而，胃排空严重延迟（半排空时间超过200分钟）的患者餐后饱腹感增加（P = 0.012）、腹痛（P = 0.026）、腹胀（P = 0.044）、早饱感（P = 0.018）、症状综合评分（P = 0.005），且生活质量较低（P = 0.018）。如果胃排空计算仅限于前4小时样本，则不再观察到这种关联。
在总体消化不良人群中，症状、生活质量与胃排空之间没有关联。然而，在胃排空严重延迟的患者亚组中，症状、生活质量与胃排空延迟之间存在关联。建议进行8小时的胃排空测量。
