Hershey T, Craft S, Bhargava N, White N H
Department of Psychology, Washington University in St. Louis, USA.
J Int Neuropsychol Soc. 1997 Nov;3(6):509-20.
Previous studies of the neuropsychological consequences of insulin dependent diabetes mellitus (IDDM) have had mixed and often contradictory results, possibly due to the heterogeneity of the samples and neuropsychological measures, and a lack of specific hypotheses. In order to address this problem, we focused on the effect of severe hypoglycemia on memory functioning in a relatively homogeneous sample of childhood-onset IDDM patients. Given the deleterious effects of hypoglycemia on medial temporal lobe structures (e.g., hippocampus) and the relationship between medial temporal damage and declarative memory functioning, we hypothesized that those patients who had experienced severe hypoglycemia would demonstrate impaired declarative memory and spared nondeclarative memory functioning. Results of the study were generally consistent with this hypothesis, although some impact of hypoglycemia was observed on perceptual priming ability.
先前关于胰岛素依赖型糖尿病（IDDM）神经心理学后果的研究结果不一，且常常相互矛盾，这可能是由于样本和神经心理学测量方法的异质性，以及缺乏具体的假设。为了解决这个问题，我们聚焦于严重低血糖对儿童期发病的IDDM患者相对同质样本的记忆功能的影响。鉴于低血糖对内侧颞叶结构（如海马体）的有害影响以及内侧颞叶损伤与陈述性记忆功能之间的关系，我们假设经历过严重低血糖的患者会表现出陈述性记忆受损而非陈述性记忆功能保留。尽管观察到低血糖对知觉启动能力有一定影响，但研究结果总体上与这一假设一致。
