Andreis P G, Neri G, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):17-9. doi: 10.1016/s0960-0760(97)00066-6.
The effects of luteinizing hormone-releasing hormone (LH-RH) on the function of rat adrenal cortex were investigated by using dispersed zona glomerulosa (capsular) and zona fasciculata-reticularis (inner) cells. LH-RH increased basal (but not adrenocorticotropic hormone (ACTH)-stimulated) corticosterone secretion of inner cells, without affecting either aldosterone or corticosterone production by capsular cells. LH-RH markedly raised basal (but not ACTH-enhanced) cyclic-AMP release by inner cells. The corticosterone secretagogue action of LH-RH was abolished by the protein kinase A inhibitor H-89. The conclusion is drawn that LH-RH specifically stimulates adrenal glucocorticoid secretion in rats through the activation of the adenylate cyclase signaling pathway.
通过使用分散的球状带（被膜）和束状带-网状带（内部）细胞，研究了促黄体生成激素释放激素（LH-RH）对大鼠肾上腺皮质功能的影响。LH-RH增加了内部细胞的基础（但不增加促肾上腺皮质激素（ACTH）刺激的）皮质酮分泌，而不影响被膜细胞的醛固酮或皮质酮生成。LH-RH显著提高了内部细胞的基础（但不增加ACTH增强的）环磷酸腺苷释放。蛋白激酶A抑制剂H-89消除了LH-RH的皮质酮促分泌作用。得出的结论是，LH-RH通过激活腺苷酸环化酶信号通路特异性刺激大鼠肾上腺糖皮质激素分泌。
