Malendowicz L K, Nussdorfer G G, Markowska A
Department of Histology and Embryology, School of Medicine, Poznan, Poland.
J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):123-5. doi: 10.1016/s0960-0760(97)00082-4.
Leptin is a peptide secreted by adipose tissue, which regulates satiety, metabolic rate, and thermogenesis. Since corticosteroids regulate the mass of adipose tissue, and leptin synthesis and secretion by adipocytes, we have examined whether leptin in turn is able to directly affect adrenal steroid secretion. Recombinant murine leptin was found to increase basal aldosterone and corticosterone production by dispersed rat zona glomerulosa and zona fasciculata-reticularis cells, respectively. In contrast, leptin did not affect maximally ACTH (10(-9) M)-stimulated steroid secretion. These findings, coupled with the recent observation that leptin is able to stimulate hypothalamo-pituitary CRH-ACTH system, may indicate a role for leptin as a regulator of adrenocortical function in the rat.
瘦素是一种由脂肪组织分泌的肽，它调节饱腹感、代谢率和产热。由于皮质类固醇调节脂肪组织的质量以及脂肪细胞中瘦素的合成和分泌，我们研究了瘦素是否反过来能够直接影响肾上腺类固醇的分泌。结果发现，重组鼠瘦素分别增加了分散的大鼠肾小球带和束状带-网状带细胞基础醛固酮和皮质酮的产生。相比之下，瘦素不影响促肾上腺皮质激素（10⁻⁹ M）最大刺激下的类固醇分泌。这些发现，再加上最近观察到瘦素能够刺激下丘脑-垂体促肾上腺皮质激素释放激素-促肾上腺皮质激素系统，可能表明瘦素在大鼠肾上腺皮质功能调节中发挥作用。
