比较二氧化碳生成法（BACTEC法）和活菌计数法以确定抗分枝杆菌药物对鸟分枝杆菌复合群的抗生素后效应。
Comparison of CO2 generation (BACTEC) and viable-count methods to determine the postantibiotic effect of antimycobacterial agents against Mycobacterium avium complex.
作者信息
Zhanel G G, Saunders M H, Wolfe J N, Hoban D J, Karlowsky J A, Kabani A M
机构信息
Department of Medical Microbiology and Faculty of Pharmacy, University of Manitoba, Health Sciences Centre, Winnipeg, Canada.
出版信息
Antimicrob Agents Chemother. 1998 Jan;42(1):184-7. doi: 10.1128/AAC.42.1.184.
Abstract
The postantibiotic effects (PAEs) of antimycobacterial agents determined with a BACTEC TB-460 instrument (CO2 production) and by a traditional viable-count method against Mycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2-h exposure to 2x the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.
摘要
用BACTEC TB - 460仪器（二氧化碳产生量）和传统活菌计数法测定的抗分枝杆菌药物对鸟分枝杆菌复合群（MAC）的抗生素后效应（PAEs）无显著差异（P>0.05）。在2倍最低抑菌浓度（MIC）下暴露2小时后，PAEs最长的是阿米卡星（10.3小时）、利福平（9.7小时）和利福布汀（9.5小时），而PAEs最短的是氯法齐明（1.7小时）和乙胺丁醇（1.1小时）暴露后。二氧化碳生成是测定体外抗MAC的PAEs的有效手段。
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