Tsui S Y, Yew W W, Li M S, Chan C Y, Cheng A F
Department of Microbiology, Chinese University of Hong Kong.
Antimicrob Agents Chemother. 1993 May;37(5):1001-3. doi: 10.1128/AAC.37.5.1001.
A study of postantibiotic effects (PAE) in vitro of amikacin and ofloxacin on Mycobacterium fortuitum isolates from sternotomy wounds by use of the dilution method for drug removal showed that both drugs exhibited good bactericidal activities, with the PAE of amikacin lasting from 13.5 to 27.6 h and the PAE of ofloxacin lasting from 1.2 to 5.0 h. These laboratory results concur with our experience of the efficacy of once-daily dosing with these drugs in the treatment of infections caused by M. fortuitum. These data may have therapeutic implications in guiding the scheduling of the administration of drugs in these infections, which require a long duration of therapy.
采用药物去除稀释法对胸骨切开术伤口分离出的偶然分枝杆菌进行丁胺卡那霉素和氧氟沙星体外抗生素后效应（PAE）研究，结果表明两种药物均具有良好的杀菌活性，丁胺卡那霉素的PAE持续13.5至27.6小时，氧氟沙星的PAE持续1.2至5.0小时。这些实验室结果与我们使用这些药物每日一次给药治疗偶然分枝杆菌感染的疗效经验相符。这些数据可能对指导这些需要长期治疗的感染的给药方案具有治疗意义。
