Franck-Lissbrant I, Häggström S, Damber J E, Bergh A
Department of Pathology, Umeå University, Sweden.
Endocrinology. 1998 Feb;139(2):451-6. doi: 10.1210/endo.139.2.5683.
The castration-induced regression and testosterone stimulated regrowth of the vasculature in the rat ventral prostate lobe were studied using stereological techniques. Seven days after castration, the endothelial cell proliferation rate (bromodeoxyuridine labeling index); the total weights of blood vessel walls, blood vessel lumina, endothelial cells, glandular epithelial cells; and total organ weight were all decreased. Within 2 days after sc treatment with testosterone, the total weights of blood vessel walls, endothelial cells, and vascular lumina, as well as the endothelial cell proliferation rate, were all normalized. In contrast to the rapid response of the vasculature, the total weight of glandular epithelium and total organ weight were not normalized during the 4 days of testosterone treatment. Growth of the vasculature apparently precedes growth of the glandular epithelium. The testosterone- dependent factors stimulating the vasculature are unknown, but factors derived from epithelial cells, mast cells (which accumulate in the prostate during the first day of testosterone treatment), and tissue macrophages could all be involved. Castration-induced regression and testosterone-stimulated regrowth of the prostatic vasculature can be used as an experimental model to study factors regulating angiogenesis and organ growth in the prostate.
利用体视学技术研究了去势诱导的大鼠腹侧前列腺叶血管系统的退化以及睾酮刺激的血管系统再生长。去势7天后，内皮细胞增殖率（溴脱氧尿苷标记指数）、血管壁、血管腔、内皮细胞、腺上皮细胞的总重量以及器官总重量均下降。在用睾酮皮下注射治疗2天内，血管壁、内皮细胞和血管腔的总重量以及内皮细胞增殖率均恢复正常。与血管系统的快速反应形成对比的是，在睾酮治疗的4天内，腺上皮的总重量和器官总重量并未恢复正常。血管系统的生长显然先于腺上皮的生长。刺激血管系统的睾酮依赖性因子尚不清楚，但来自上皮细胞、肥大细胞（在睾酮治疗的第一天在前列腺中积聚）和组织巨噬细胞的因子都可能参与其中。去势诱导的前列腺血管系统退化和睾酮刺激的再生长可作为研究调节前列腺血管生成和器官生长的因子的实验模型。
