Majtán V, Hostacká A
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Folia Microbiol (Praha). 1996;41(3):228-32. doi: 10.1007/BF02814621.
The postantibiotic effect (PAE) (postantibiotic phase induced by 2x or 4x MIC) as well as the postantibiotic effect of subinhibitory concentrations (0.1x, 0.2x and 0.3x MIC) (PA SME) of netilmicin, tobramycin, ciprofloxacin and pefloxacin affected the production of the virulence factor alginate by a P. aeruginosa strain. Aminoglycosides and ciprofloxacin at a concentration of 4x MIC inhibited the alginate production more significantly than 2x MIC. Suprainhibitory concentrations of aminoglycosides were more effective than pefloxacin (2x or 4x MIC) and ciprofloxacin (2x MIC). PA SME demonstrated by the above antibiotics (with the exception of ciprofloxacin 2x MIC + 0.1x MIC) suppressed alginate production more efficiently.
奈替米星、妥布霉素、环丙沙星和培氟沙星的抗生素后效应（PAE）（由2倍或4倍MIC诱导的抗生素后阶段）以及亚抑菌浓度（0.1倍、0.2倍和0.3倍MIC）的抗生素后效应（PA SME）影响了铜绿假单胞菌菌株毒力因子藻酸盐的产生。浓度为4倍MIC的氨基糖苷类药物和环丙沙星比2倍MIC更显著地抑制藻酸盐的产生。氨基糖苷类药物的超抑菌浓度比培氟沙星（2倍或4倍MIC）和环丙沙星（2倍MIC）更有效。上述抗生素表现出的PA SME（环丙沙星2倍MIC + 0.1倍MIC除外）能更有效地抑制藻酸盐的产生。
