Dupont M J, Lapointe J R
Research Center, Université de Montréal, Quebec, Canada.
J Antimicrob Chemother. 1995 Jul;36(1):231-6. doi: 10.1093/jac/36.1.231.
The effects of subinhibitory concentrations of roxithromycin (16 mg/L) or rifampicin (16 mg/L) on alginate production by Pseudomanas aeruginosa were investigated. The weight of purified alginate from antibiotic-free cultures was significantly greater (52.5 +/- 24.0 mg, range 22.4-109.5), compared with alginate from cultures bacteria exposed to sub-MIC of roxithromycin (21.9 +/- 17.0, 0.0-42.1 (P < or = 0.037)) and to sub-MIC of rifampicin (28.6 +/- 15.0, 2.9-47.5 (P < or = 0.038)). Chromatographic analysis of hydrolysed and chemically transformed sub-units of alginate revealed that the presence and the molar ratio of D-mannuronic acid and L-guluronic acid were not affected in the remnant alginate exposed to sub-MIC of roxithromycin in contrast to that in the remnant alginate exposed to sub-MIC of rifampicin.
研究了亚抑菌浓度的罗红霉素（16毫克/升）或利福平（16毫克/升）对铜绿假单胞菌藻酸盐产生的影响。与暴露于罗红霉素亚最小抑菌浓度（21.9±17.0，0.0 - 42.1（P≤0.037））和利福平亚最小抑菌浓度（28.6±15.0，2.9 - 47.5（P≤0.038））的培养物中的藻酸盐相比，无抗生素培养物中纯化藻酸盐的重量显著更大（52.5±24.0毫克，范围22.4 - 109.5）。对藻酸盐水解和化学转化亚基的色谱分析表明，与暴露于利福平亚最小抑菌浓度的残留藻酸盐相比，暴露于罗红霉素亚最小抑菌浓度的残留藻酸盐中D - 甘露糖醛酸和L - 古洛糖醛酸的存在及摩尔比未受影响。
