Monteiro M A, Rasko D, Taylor D E, Perry M B
Institute for Biological Sciences, National Research Council, Ottawa, Ontario K1A OR6, Canada.
Glycobiology. 1998 Jan;8(1):107-12. doi: 10.1093/glycob/8.1.107.
The O-antigen chain from the lipopolysaccharide of Helicobacter pylori strain UA861 was determined to be composed of an elongated type 2 N -acetyllactosamine backbone, -[-->3)-beta-D-Gal-(1-->4)-beta-D-GlcNAc-(1-]n-->, with approximately half of the GlcNAc units carrying a terminal alpha-d-Glc residue at the O -6 position. The O-chain of H.pylori UA861 was terminated by a N -acetyllactosamine [beta-D-Gal-(1-->4)-beta-D-GlcNAc] (LacNAc) epitope and did not express terminal Lewis X or Lewis Y blood-group determinants as previously found in other H.pylori strains. The absence of terminal Lewis X and Lewis Y blood-group epitopes and the replacement of Fuc by Glc as a side chain in the O-chain of H.pylori UA861 represents yet another type of lipopolysaccharide structure from H.pylori species. These structural differences in H.pylori lipopolysaccharide molecules carry implications with regard to possible different pathogenic events between strains and respective hosts.
幽门螺杆菌菌株UA861脂多糖的O抗原链被确定为由一种延长型2 N-乙酰乳糖胺主链组成，即-[→3)-β-D-半乳糖-(1→4)-β-D-葡萄糖胺-(1-]n-，其中大约一半的葡萄糖胺单元在O-6位置带有一个末端α-D-葡萄糖残基。幽门螺杆菌UA861的O链由一个N-乙酰乳糖胺[β-D-半乳糖-(1→4)-β-D-葡萄糖胺]（LacNAc）表位终止，并且不像之前在其他幽门螺杆菌菌株中发现的那样表达末端Lewis X或Lewis Y血型决定簇。幽门螺杆菌UA861的O链中缺乏末端Lewis X和Lewis Y血型表位以及用葡萄糖取代岩藻糖作为侧链，代表了幽门螺杆菌属的另一种脂多糖结构类型。幽门螺杆菌脂多糖分子中的这些结构差异对于菌株与各自宿主之间可能存在的不同致病事件具有影响。
