Israel Dawn A, Peek Richard M
Department of Medicine; Division of Gastroenterology, Nashville, TN USA.
Gut Microbes. 2010 Mar;1(2):119-127. doi: 10.4161/gmic.1.2.11991.
Microbial pathogens contribute to the development of more than 1 million cases of cancer per year. Gastric adenocarcinoma is the second leading cause of cancer-related death in the world, and gastritis induced by Helicobacter pylori is the strongest known risk factor for this malignancy. H. pylori colonizes the stomach for years, not days or weeks, as is usually the case for bacterial pathogens and it always induces inflammation; however, only a fraction of colonized individuals ever develop disease. Identification of mechanisms through which H. pylori co-opts host defenses to facilitate its own persistence will not only improve diagnostic and therapeutic modalities, but may also provide insights into other diseases that arise within the context of long-term pathogen-initiated inflammatory states, such as chronic viral hepatitis and hepatocellular carcinoma.
微生物病原体每年导致超过100万例癌症的发生。胃腺癌是全球癌症相关死亡的第二大主要原因，而幽门螺杆菌引起的胃炎是已知的这种恶性肿瘤最强的危险因素。幽门螺杆菌在胃中定植数年，而不像通常的细菌病原体那样仅定植数天或数周，并且它总是引发炎症；然而，只有一小部分被定植的个体最终会发病。确定幽门螺杆菌利用宿主防御机制以促进自身持续存在的机制，不仅将改善诊断和治疗方式，还可能为在长期病原体引发的炎症状态下出现的其他疾病提供见解，例如慢性病毒性肝炎和肝细胞癌。
