血清脂蛋白和脂质浓度的遗传度估计。

Estimates of the heritability of serum lipoprotein and lipid concentrations.

作者信息

Weinberg R, Avet L M, Gardner M J

出版信息

Clin Genet. 1976 Jun;9(6):588-92. doi: 10.1111/j.1399-0004.1976.tb01617.x.

DOI:10.1111/j.1399-0004.1976.tb01617.x

Abstract

Heritability (h2) of a serum lipid or a serum lipoprotein concentration is the proportion of variability in that concentration, among individuals, which is associated with heredity. We derive a familiar formula for estimating heritability (h2) from a simple linear model for inheritance. The formula was implied by Fisher (1918) and by Wright (1921); it was derived from a consideration of variances by Jensen (1967), and from a consideration of path coefficients by Rao et al. (1974). The estimate of heritability (ĥ2) is ĥ2 = 2(rMZ - rDZ) for twin studies, where rMZ and rDZ are the sample intraclass correlation coefficients among monozygous and dizygous twins, respectively. We calculate ĥ2 for some published twin data (Heiberg 1974) on serum lipoprotein and serum lipid concentrations.

摘要

血清脂质或血清脂蛋白浓度的遗传力（h2）是个体间该浓度变异性中与遗传相关的比例。我们从一个简单的遗传线性模型推导出一个估算遗传力（h2）的常用公式。该公式由费希尔（1918年）和赖特（1921年）提出；詹森（1967年）通过考虑方差得出该公式，拉奥等人（1974年）则通过考虑通径系数得出。对于双胞胎研究，遗传力（ĥ2）的估计值为ĥ2 = 2（rMZ - rDZ），其中rMZ和rDZ分别是同卵双胞胎和异卵双胞胎样本中的组内相关系数。我们根据一些已发表的关于血清脂蛋白和血清脂质浓度的双胞胎数据（海伯格，1974年）计算了ĥ2。