Girgenti A J, Whitford T W, Cory J G
Enzyme. 1976;21(3):225-31. doi: 10.1159/000458862.
Transfer RNA nucleotidyl transferase from Ehrlich tumor cells was inhibited by proflavine sulfate and ethidium bromide but not by actinomycin D, chromomycin, rifamycin SV, rifampin, daunomycin, or alpha-amanitin. Complete inhibition of nucleotidyl transferase activity was attained at a final concentration of 1 mmol/1 proflavine sulfate, while 2 mmol/1 ethidium bromide was required to completely inhibit the enzyme. CMP incorporation into tRNA was more sensitive to both proflavine sulfate and ethidium bromide than was AMP incorporation.
艾氏腹水瘤细胞的转移核糖核酸核苷酸转移酶受到硫酸原黄素和溴化乙锭的抑制，但不受放线菌素D、色霉素、利福霉素SV、利福平、柔红霉素或α-鹅膏蕈碱的抑制。在硫酸原黄素终浓度为1 mmol/L时，核苷酸转移酶活性被完全抑制，而溴化乙锭完全抑制该酶则需要终浓度为2 mmol/L。与AMP掺入相比，CMP掺入到tRNA中对硫酸原黄素和溴化乙锭都更敏感。
