Davet J, Clavel B, Datas L, Mani-Ponset L, Maurel D, Herbuté S, Viso M, Hinds W, Jarvi J, Gabrion J
Centre National de la Recherche Scientifique, Université de Montpellier II, France.
J Appl Physiol (1985). 1998 Jan;84(1):19-29. doi: 10.1152/jappl.1998.84.1.19.
To determine when choroidal structures were restored after readaptation to Earth gravity or orthostatic position, fine structure and protein distribution were studied in rat choroid plexus dissected either 6 h [Space Life Sciences-2 (SLS-2) experiments] or 2 days [National Institutes of Health-Rodent 1 (NIH-R1) experiments] after a spaceflight, or 6 h after head-down tilt (HDT) experiments. Apical alterations were noted in choroidal cells from SLS-2 and HDT animals, confirming that weightlessness impaired choroidal structures and functions. However, the presence of small apical microvilli and kinocilia and the absence of vesicle accumulations showed that the apical organization began to be restored rapidly after landing. Very enlarged apical microvilli appeared after 2 days on Earth, suggesting increased choroidal activity. However, as distributions of ezrin and carbonic anhydrase II remained altered in both flight and suspended animals after readaptation to Earth gravity, it was concluded that choroidal structures and functions were not completely restored, even after 2 days in Earth's gravity.
为了确定重新适应地球重力或直立姿势后脉络膜结构何时恢复，研究了在太空飞行后6小时[太空生命科学-2（SLS-2）实验]或2天[美国国立卫生研究院-啮齿动物1（NIH-R1）实验]，或头低位倾斜（HDT）实验后6小时解剖的大鼠脉络丛的精细结构和蛋白质分布。在SLS-2和HDT动物的脉络膜细胞中观察到顶端改变，证实失重损害了脉络膜结构和功能。然而，小的顶端微绒毛和动纤毛的存在以及囊泡积累的缺失表明，着陆后顶端组织开始迅速恢复。在地球上2天后出现非常增大的顶端微绒毛，表明脉络膜活性增加。然而，由于在重新适应地球重力后，飞行和悬吊动物中埃兹蛋白和碳酸酐酶II的分布仍然改变，得出的结论是，即使在地球重力环境中2天后，脉络膜结构和功能也没有完全恢复。
