Giamberardino M A, Affaitati G, Valente R, Iezzi S, Vecchiet L
Pathophysiology of Pain Laboratory, Institute of Medical Pathophysiology G. D'Annunzio University of Chieti, Italy.
Brain Res. 1997 Nov 7;774(1-2):234-8. doi: 10.1016/s0006-8993(97)81711-8.
This study examined estrous differences in the characteristics of behavioral crises of visceral pain in female rats video-taped throughout a 4-day period after implantation of an artificial stone in one ureter. All animals continued to have a regular cycle after ureteral surgery. In the recording period, the percentage of time spent in crises was significantly higher during metestrus/diestrus (M/D) than during proestrus/estrus (P/E) (P < 0.001, chi2-test). Mean duration and complexity of crises were slightly higher in M/D than in P/E, but the difference was not significant. The results in this animal model show an enhancement of ureteral pain sensitivity in M/D, a finding in line with the clinical observation, in fertile women with urinary calculosis, of a greater incidence of colics in the perimenstrual period (equivalent to M/D in rats).
本研究对雌性大鼠一侧输尿管植入人造结石后4天内进行录像，观察内脏痛行为危机特征的发情差异。所有动物输尿管手术后仍维持正常周期。在记录期内，动情后期/间情期（M/D）出现危机的时间百分比显著高于发情前期/发情期（P/E）（P<0.001，卡方检验）。M/D期危机的平均持续时间和复杂性略高于P/E期，但差异不显著。该动物模型的结果显示，M/D期输尿管疼痛敏感性增强，这一发现与临床观察结果一致，即患有尿路结石病的育龄妇女在围经期（相当于大鼠的M/D期）绞痛发生率更高。
