Schall V T, de Vasconcellos M C, de Souza C P, Baptista D F
Department of Biology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Am J Trop Med Hyg. 1998 Jan;58(1):7-10. doi: 10.4269/ajtmh.1998.58.7.
The present study describes the action of the latex of Euphorbia splendens var. hislopii (E. milli) on species of the genus Bulinus and on Biomphalaria pfeifferi, intermediate hosts of schistosomiasis in Africa, and the Brazilian snails B. glabrata, B. tenagophila, and B. straminea, intermediate hosts of schistosomiasis in Brazil. The impact of the latex on the egg masses and embryos of B. glabrata was also evaluated. Using the standardized methodology of the World Health Organization for testing plant-derived molluscicides, we obtained a 90% lethal dose (LD90) ranging from 0.13 ppm for B. glabrata subjected to lyophilized latex to 4.0 ppm for B. pfeifferi tested with the natural latex. This material has proved to be one of the most potent and specific plant molluscicides discovered thus far, presenting advantages in terms of application so that it could be used in programs involving community participation in endemic areas in both Brazil and Africa.
本研究描述了猩猩草变种希斯洛普大戟（一品红）的乳胶对非洲血吸虫病中间宿主泡螺属物种和费氏双脐螺，以及巴西血吸虫病中间宿主光滑双脐螺、嗜气管双脐螺和淡黄双脐螺的作用。还评估了该乳胶对光滑双脐螺卵块和胚胎的影响。使用世界卫生组织测试植物源杀螺剂的标准化方法，我们获得的90%致死剂量（LD90）范围为：冻干乳胶处理的光滑双脐螺为0.13 ppm，天然乳胶测试的费氏双脐螺为4.0 ppm。这种物质已被证明是迄今为止发现的最有效和最具特异性的植物杀螺剂之一，在应用方面具有优势，因此可用于巴西和非洲流行地区涉及社区参与的项目。
