Mello-Silva Clélia Christina, Vasconcellos Maurício Carvalho de, Pinheiro Jairo, Rodrigues Maria de Lurdes de Azevedo
Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, 23890-000 Seropédica, RJ, Brazil.
Mem Inst Oswaldo Cruz. 2006 Feb;101(1):3-8. doi: 10.1590/s0074-02762006000100002. Epub 2006 Mar 30.
Molluscides have been used as one of the strategies to control schistosomiasis. Many plant extracts with molluscidal effects have been tested, but the action of the latex of Euphorbia splendens var. hislopii is considered the most promising because it meets the recommendations of the World Health Organization (WHO). The objective of this study was to determine the lethal dose and identify the effects of the different doses of latex of E. splendens var. hislopii on the physiology of Biomphalaria glabrata submitted to treatment for 24 h. The concentrations of glucose, uric acid and total proteins in the hemolymph and of glycogen in the digestive gland and cephalopodal mass were determined. The LD50 value was 1 mg/l. The highest escape index was found to be at a concentration of 0.6 mg/l. The results showed that the latex of E. splendens var. hislopii caused a sharp reduction in the reserves of glycogen in the digestive gland and elevation of the protein content in the hemolymph of B. glabrata.
杀螺剂已被用作控制血吸虫病的策略之一。许多具有杀螺作用的植物提取物都经过了测试，但大戟科大戟属希斯洛普大戟乳胶的作用被认为是最有前景的，因为它符合世界卫生组织（WHO）的建议。本研究的目的是确定致死剂量，并确定不同剂量的希斯洛普大戟乳胶对接受24小时治疗的光滑双脐螺生理的影响。测定了血淋巴中葡萄糖、尿酸和总蛋白的浓度，以及消化腺和头足部组织中糖原的浓度。半数致死剂量（LD50）值为1毫克/升。发现最高逃避指数出现在浓度为0.6毫克/升时。结果表明，希斯洛普大戟乳胶导致光滑双脐螺消化腺中糖原储备急剧减少，血淋巴中蛋白质含量升高。
