Bjure J, Uvebrant P, Vestergren E, Hagberg B
Department of Pediatric Clinical Physiology, Sahlgren University Hospital, Göteborg, Sweden.
Eur Child Adolesc Psychiatry. 1997;6 Suppl 1:64-6.
Sixteen Rett syndrome (RS) girls and 1 24 year old RS woman were compared with 16 neurologically healthy children as to the regional cerebral blood flow (rCBF). Hypoperfusion of the frontal lobes and parts of the midbrain was found in RS, with significant differences to controls at latest by the age of three to four years. The findings were in accordance with previous reports of morphological, neuroradiological and functional abnormalities in these areas, compatible with a statement that structures in the midbrain and in the frontal lobes may have particular pathophysiological relevance in RS.
将16名雷特综合征（RS）女童和1名24岁的RS女性与16名神经功能正常的儿童进行了脑局部血流量（rCBF）的比较。在RS患者中发现额叶和部分中脑存在灌注不足，最迟在3至4岁时与对照组存在显著差异。这些发现与先前关于这些区域形态学、神经放射学和功能异常的报道一致，这表明中脑和额叶的结构可能在RS中具有特殊的病理生理学意义。
