细胞凋亡：一种新的药效学终点。 - Suppr

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超能文献

Apoptosis: a new pharmacodynamic endpoint.

作者信息

Au J L, Panchal N, Li D, Gan Y

机构信息

College of Pharmacy and Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA.

出版信息

Pharm Res. 1997 Dec;14(12):1659-71. doi: 10.1023/a:1012159208559.

DOI:10.1023/a:1012159208559

PMID:9453051

Abstract

摘要

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.DFF是一种异二聚体蛋白，在细胞凋亡过程中，它在半胱天冬酶-3下游发挥作用，触发DNA片段化。

Cell. 1997 Apr 18;89(2):175-84. doi: 10.1016/s0092-8674(00)80197-x.

Mechanisms of apoptotic cell death.凋亡性细胞死亡的机制。

Leukemia. 1997 Apr;11(4):457-65. doi: 10.1038/sj.leu.2400626.

Controlling cell death.控制细胞死亡。

Science. 1997 Feb 21;275(5303):1081-2. doi: 10.1126/science.275.5303.1081.

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).TRAMP，一种与肿瘤坏死因子受体1和Fas（Apo-1/CD95）具有序列同源性的新型凋亡介导受体。

Immunity. 1997 Jan;6(1):79-88. doi: 10.1016/s1074-7613(00)80244-7.

Apoptosis and disease: regulation and clinical relevance of programmed cell death.细胞凋亡与疾病：程序性细胞死亡的调控及其临床意义

Annu Rev Med. 1997;48:267-81. doi: 10.1146/annurev.med.48.1.267.

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.CRADD，一种新的半胱天冬酶-2的人类凋亡衔接分子，以及FasL/肿瘤坏死因子受体相互作用蛋白RIP。

Cancer Res. 1997 Feb 15;57(4):615-9.

Apoptosis by death factor.死亡因子介导的细胞凋亡

Cell. 1997 Feb 7;88(3):355-65. doi: 10.1016/s0092-8674(00)81874-7.

p53, the cellular gatekeeper for growth and division.p53，细胞生长和分裂的守门人。

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.细胞色素c从线粒体的释放：Bcl-2调控细胞凋亡的主要位点。

Science. 1997 Feb 21;275(5303):1132-6. doi: 10.1126/science.275.5303.1132.

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.Bcl-2对细胞凋亡的预防作用：线粒体中细胞色素c的释放受阻。

Science. 1997 Feb 21;275(5303):1129-32. doi: 10.1126/science.275.5303.1129.

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