Blatchley F R, Donovan B T
J Endocrinol. 1976 Jul;70(1):39-45. doi: 10.1677/joe.0.0700039.
The response of the guinea-pig corpus luteum to the luteolytic influence of glass beads placed in the uterus, or to prostaglandin administration, was followed by assay of the progesterone content of blood samples collected daily. Following the introduction of glass beads into the uterus early in the cycle, the secretion of progesterone was curtailed. Treatment with prostaglandin F2alpha over days 4-6 or 6-8 of the cycle temporarily depressed progesterone release without shortening the life of the corpora lutea. When the drug was administered over days 8-10, 10-12 or 12-14 the depression in progesterone was not followed by any recovery. These observations indicate that the response of the corpora lutea to a luteolytic influence changes during the oestrous cycle.
通过每天采集血样测定孕酮含量，来跟踪豚鼠黄体对置于子宫内玻璃珠的溶黄体作用或对给予前列腺素的反应。在周期早期将玻璃珠引入子宫后，孕酮分泌减少。在周期的第4 - 6天或6 - 8天用前列腺素F2α治疗会暂时抑制孕酮释放，但不会缩短黄体寿命。当在第8 - 10天、10 - 12天或12 - 14天给予该药物时，孕酮降低后没有任何恢复。这些观察结果表明，黄体对溶黄体作用的反应在发情周期中会发生变化。
