Young S N, Etienne P, Sourkes T L
J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):239-43. doi: 10.1136/jnnp.39.3.239.
Tryptophan was measured in the cisternal CSF and brains of rats. In untreated rats there was a significant but not very close correlation between the tryptophan concentration in these two compartments. Factors that change the brain tryptophan concentration such as starvation, glucose feeding, and lithium treatment affected the CSF tryptophan in the same way as the brain tryptophan. Diurnal changes were parallel for brain and CSF. When we take into account our knowledge of the disposition of tryptophan in human CSF, these data suggest that measurement of lumbar CSF tryptophan in man may be a useful approach to the study of human brain tryptophan. However, because the correlation between brain and CSF is not very close, measurements on CSF tryptophan would be more meaningful in groups of patients than in individuals.
在大鼠的脑池脑脊液和大脑中测量了色氨酸。在未经治疗的大鼠中，这两个腔室中的色氨酸浓度之间存在显著但并非非常紧密的相关性。改变脑色氨酸浓度的因素，如饥饿、葡萄糖喂养和锂治疗，对脑脊液色氨酸的影响与对脑色氨酸的影响相同。大脑和脑脊液的昼夜变化是平行的。考虑到我们对色氨酸在人类脑脊液中分布情况的了解，这些数据表明，测量人类腰椎脑脊液中的色氨酸可能是研究人类脑色氨酸的一种有用方法。然而，由于脑和脑脊液之间的相关性不是非常紧密，脑脊液色氨酸的测量在患者群体中比在个体中更有意义。
