[结节病患者分离出的分枝杆菌与抗结核抗体的相互作用]
[Interaction of Mycobacteria isolated from sarcoidosis patients with antituberculosis antibodies].
作者信息
Litvinov V I, Chernousova L N, Safonova S G, Kalinina O A, Kulikovskaia N V, Kapina M A, Dem'ianenko N V
机构信息
Central NII of Tuberculosis PAMN, Moscow.
出版信息
Probl Tuberk. 1997(5):36-8.
In 80% of cases, antituberculosis antibodies from the sera of patients with tuberculosis were ascertained to react in enzyme immunoassay (EIA) with antigens (ultrasound disintegrants (USDs)) of reverse mycobacteria isolated (initially) from patients with sarcoidosis. The USDs of reverse mycobacteria isolated from patients with sarcoidosis reacted in EIA with monoclonal antibodies (MAb) against M. tuberculosis complex antigens (unique and crossover). Both common and distinctive (unique) antigenic determinants were detected via MAb against different mycobacterial types by immunoblotting in the antigenic complexes of M. tuberculosis H37Rv and reverse strains isolated from patients with sarcoidosis.
在80%的病例中，经测定，结核病患者血清中的抗结核抗体在酶免疫测定（EIA）中与（最初）从结节病患者中分离出的反向分枝杆菌的抗原（超声崩解产物（USDs））发生反应。从结节病患者中分离出的反向分枝杆菌的USDs在EIA中与针对结核分枝杆菌复合抗原（独特和交叉）的单克隆抗体（MAb）发生反应。通过针对不同分枝杆菌类型的MAb，经免疫印迹法在结核分枝杆菌H37Rv和从结节病患者中分离出的反向菌株的抗原复合物中检测到了共同和独特（独特）的抗原决定簇。
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