Hashimoto K, Karasawa F, Satoh T
Department of Anesthesiology, National Defense Medical College, Tokorozawa.
Masui. 1997 Aug;46(8):1059-65.
We hypothetized that intrathecal (IT) midazolam (M) affects renal sympathetic nerve activity (RSNA) via benzodiazepine receptors (BZR) at the spinal cord. Under alpha-chloralose anesthesia, 26 rabbits underwent surgical procedures for the cannulation to femoral artery and vein for measuring blood pressure and infusing lactated Ringer solution, respectively. Intrathecal cannulation was performed at the 7th thoracic vertebral level. RSNA was recorded from the nerve raw between the renal artery and vein using a left flank incision. In the neuraxis-intact rabbits, IT administration of low dose M (0.50%) did not affect heart rate (HR), mean arterial pressure (MAP), and integrated RSNA (IRSNA). High concentration of M (0.5%) increased HR, decreased MAP and attenuated IRSNA significantly. In the sino-aortic denervated rabbits, IT administration of 0.5% M decreased MAP and IRSNA, but intravenous 0.2 flumazenil rapidly and significantly increased MAP and IRSNA. This finding suggests that the decrease in IRSNA followed by IT M derives from BZR. In conclusion, IT high concentration of M attenuated RSNA through BZR.
我们推测鞘内注射咪达唑仑（M）通过脊髓中的苯二氮䓬受体（BZR）影响肾交感神经活动（RSNA）。在α-氯醛糖麻醉下，26只兔子接受了分别用于股动脉插管测量血压和股静脉插管输注乳酸林格液的外科手术。在第7胸椎水平进行鞘内插管。通过左腹切口从肾动脉和静脉之间的神经干记录RSNA。在神经轴完整的兔子中，鞘内注射低剂量M（0.50%）不影响心率（HR）、平均动脉压（MAP）和综合RSNA（IRSNA）。高浓度M（0.5%）显著增加HR、降低MAP并减弱IRSNA。在去窦弓神经的兔子中，鞘内注射0.5% M降低MAP和IRSNA，但静脉注射0.2氟马西尼迅速且显著增加MAP和IRSNA。这一发现表明鞘内注射M后IRSNA的降低源于BZR。总之，鞘内高浓度M通过BZR减弱RSNA。
