Baird D D, Wilcox A J, Weinberg C R, Kamel F, McConnaughey D R, Musey P I, Collins D C
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Hum Reprod. 1997 Dec;12(12):2607-13. doi: 10.1093/humrep/12.12.2607.
We compared daily urinary concentrations of oestrogen and progesterone metabolites in paired menstrual cycles (conception and non-conception) from 32 women. Volunteers with no known fertility problems were enrolled in the study at the time they began trying to become pregnant. They collected first-morning urine specimens and kept daily records of menstrual bleeding and sexual intercourse for 6 months or until they became clinically pregnant. Intercourse in non-conception cycles was close to the time of ovulation so that failure to conceive was caused by factors other than poorly timed intercourse. Compared with non-conception cycles, conception cycles had a steeper early luteal rise in progesterone and higher mid-luteal oestrogen and progesterone concentrations. These hormonal characteristics may be markers of better quality cycles, but because all these differences were in the luteal phase, we cannot rule out the possibility that the preimplantation embryo had stimulated early increases in steroid production. We propose an analysis strategy that could help support or refute the importance of preimplantation embryonic signalling, but our small sample size limits our own conclusions about this mechanism.
我们比较了32名女性配对月经周期（受孕和未受孕）中雌激素和孕酮代谢物的每日尿液浓度。在开始尝试怀孕时，无已知生育问题的志愿者被纳入该研究。她们收集晨尿样本，并持续6个月记录每日月经出血和性交情况，直至临床受孕。未受孕周期的性交时间接近排卵时间，因此未能受孕是由性交时间不当以外的因素导致的。与未受孕周期相比，受孕周期中孕酮在黄体早期上升更为陡峭，黄体中期雌激素和孕酮浓度更高。这些激素特征可能是周期质量更好的标志，但由于所有这些差异都出现在黄体期，我们不能排除植入前胚胎刺激类固醇生成早期增加的可能性。我们提出了一种分析策略，有助于支持或反驳植入前胚胎信号传导的重要性，但我们的小样本量限制了我们对这一机制的结论。
