人类免疫缺陷病毒感染个体接种甲型流感病毒疫苗后中和抗体及血凝抑制抗体反应的比较。
Comparison of neutralizing and hemagglutination-inhibiting antibody responses to influenza A virus vaccination of human immunodeficiency virus-infected individuals.
作者信息
Benne C A, Kroon F P, Harmsen M, Tavares L, Kraaijeveld C A, De Jong J C
机构信息
Eijkman-Winkler Laboratory of Medical Microbiology, University Hospital Utrecht, The Netherlands.
出版信息
Clin Diagn Lab Immunol. 1998 Jan;5(1):114-7. doi: 10.1128/CDLI.5.1.114-117.1998.
Abstract
A neutralization enzyme immunoassay (N-EIA) was used to determine the neutralizing serum antibody titers to influenza A/Taiwan/1/86 (H1N1) and Beijing/353/89 (H3N2) viruses after vaccination of 51 human immunodeficiency virus (HIV) type 1-infected individuals and 10 healthy noninfected controls against influenza virus infection. Overall, the N-EIA titers correlated well with the hemagglutination-inhibition (HAI) titers that were observed in the same samples in a previous study (F. P. Kroon, J. T. van Dissel, J. C. de Jong, and R. van Furth, AIDS 8:469-476,1994). The N-EIA appeared to be more sensitive than the HAI test. Significantly more fourfold or higher rises in N-EIA titer and higher mean N-EIA titers occurred in HIV-infected individuals with > or =200 CD4+ cells per microl than in those with <200 CD4+ cells per microl.
摘要
采用中和酶免疫测定法（N-EIA），检测了51例1型人类免疫缺陷病毒（HIV）感染者和10名健康未感染者接种流感病毒疫苗后，针对甲型流感病毒/台湾/1/86（H1N1）和北京/353/89（H3N2）的血清中和抗体滴度。总体而言，N-EIA滴度与先前研究中在相同样本中观察到的血凝抑制（HAI）滴度密切相关（F.P. Kroon、J.T. van Dissel、J.C. de Jong和R. van Furth，《艾滋病》8:469-476，1994）。N-EIA似乎比HAI试验更敏感。每微升CD4+细胞≥200的HIV感染者中，N-EIA滴度有四倍或更高升高以及平均N-EIA滴度更高的情况，显著多于每微升CD4+细胞＜200的感染者。
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