Yamashita T, Ando Y, Obayashi K, Uchino M, Ando M
The First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
J Neurol Sci. 1997 Dec 9;153(1):32-4. doi: 10.1016/s0022-510x(97)00183-4.
To compare the change in nitric oxide (NO) metabolism in patients with multiple sclerosis (MS) in different clinical stages, such as exacerbation, remission, and 1-2 months after methylpredonisolone administration, we measured the nitrite and nitrate (NO2-/NO3-) levels in the cerebrospinal fluid (CSF). In the extreme stage of MS exacerbation, those levels were remarkably elevated, compared with those both after methylpredonisolone administration and remission. These results suggest that, in addition to MRI study, measurement of NO metabolites in the CSF may give information to help us understand the activity of MS and effect of drugs on the disease.
为比较不同临床阶段（如病情加重期、缓解期以及甲泼尼龙给药后1 - 2个月）的多发性硬化症（MS）患者体内一氧化氮（NO）代谢的变化，我们检测了脑脊液（CSF）中的亚硝酸盐和硝酸盐（NO2⁻/NO3⁻）水平。在MS病情加重的极期，与甲泼尼龙给药后及缓解期相比，这些水平显著升高。这些结果表明，除了MRI研究外，检测CSF中的NO代谢产物可能为我们了解MS的活动情况及药物对该疾病的影响提供信息。
