Prendergast T W, Furukawa S, Beyer A J, Browne B J, Eisen H J, Jeevanandam V
Section of Cardiac and Thoracic Surgery, Temple University Health Sciences Center, Philadelphia, Pennsylvania, USA.
Ann Thorac Surg. 1998 Jan;65(1):88-94. doi: 10.1016/s0003-4975(97)01105-3.
The effect of donor and recipient gender on the outcome of heart transplantation (HT) remains uncertain.
One hundred seventy-four patients who underwent HT were divided into four groups according to donor and recipient gender. Group A consisted of 81 men who received male donor hearts, group B of 18 women who received female donor hearts, group C of 21 women who received male donor hearts, and group D of 54 men who received female donor hearts. All patients were treated by the same group of surgeons according to standard HT protocols. Comparisons were made between groups with regard to short- and long-term outcomes.
Donor gender and recipient gender did not affect outcomes significantly. Overall, donor-recipient gender mismatching significantly increased the number of rejection episodes and reduced creatinine clearance, survival, and censored survival in the first year after HT (p < 0.05). More specifically, among female recipients, donor-recipient gender mismatching significantly increased the number of rejection episodes and decreased creatinine clearance in the first year after HT (p < 0.05); among male recipients, donor-recipient gender mismatching significantly reduced 1-year survival and censored survival to date after HT (p < 0.05).
Donor-recipient gender matching plays a significant role in determining HT outcomes.
供体和受体性别对心脏移植（HT）结果的影响仍不确定。
174例接受心脏移植的患者根据供体和受体性别分为四组。A组由81例接受男性供体心脏的男性组成，B组由18例接受女性供体心脏的女性组成，C组由21例接受男性供体心脏的女性组成，D组由54例接受女性供体心脏的男性组成。所有患者均由同一组外科医生按照标准心脏移植方案进行治疗。对各组的短期和长期结果进行比较。
供体性别和受体性别对结果无显著影响。总体而言，供体-受体性别不匹配显著增加了排斥反应的次数，并降低了心脏移植后第一年的肌酐清除率、生存率和截尾生存率（p<0.05）。更具体地说，在女性受体中，供体-受体性别不匹配显著增加了心脏移植后第一年的排斥反应次数，并降低了肌酐清除率（p<0.05）；在男性受体中，供体-受体性别不匹配显著降低了心脏移植后的1年生存率和迄今为止的截尾生存率（p<0.05）。
供体-受体性别匹配在决定心脏移植结果中起重要作用。
