Hepsen I F, Bayramlar H, Gultek A, Ozen S, Tilgen F, Evereklioglu C
Department of Ophthalmology, Turgut Ozal Medical Center, University of Inonu, Malatya, Turkey.
J Cataract Refract Surg. 1997 Dec;23(10):1572-6. doi: 10.1016/s0886-3350(97)80031-4.
To assess whether caffeic acid phenethyl ester (CAPE) prevents posterior capsule opacification (PCO) by suppressing the transformation of the lens epithelial cells.
Departments of Ophthalmology, Chemistry, and Pathology, Turgut Ozal Medical Center, University of Inonu, Malatya, Turkey.
Twenty pigmented island rabbits having phacoemulsification in their right eyes were randomized into two groups. In group 1, 10 micrograms/ml of CAPE was added to the anterior chamber irrigating solution and a 1% solution of CAPE was injected subconjunctivally for 3 weeks postoperatively. The irrigating solution in Group 2 (control) did not include CAPE. The development of PCO was assessed weekly and its density was graded by slitlamp biomicroscopy. Histologic analysis was performed 3 months after surgery.
Group 1 had clear capsules or minor PCO. Group 2 developed more severe PCO or complete opacification. The difference between the two groups was statistically significant (P = .04).
These preliminary results indicate that CAPE is effective in suppressing PCO in pigmented rabbits and may be beneficial in clinical use in humans because it has no documented harmful effects on normal cells.
评估咖啡酸苯乙酯（CAPE）是否通过抑制晶状体上皮细胞的转化来预防后囊膜混浊（PCO）。
土耳其马拉蒂亚伊诺努大学图尔古特·奥扎尔医学中心眼科、化学科和病理科。
将20只右眼行超声乳化术的有色岛兔随机分为两组。第1组，在前房冲洗液中加入10微克/毫升的CAPE，并在术后3周结膜下注射1%的CAPE溶液。第2组（对照组）的冲洗液中不包括CAPE。每周评估PCO的发展情况，并通过裂隙灯生物显微镜对其密度进行分级。术后3个月进行组织学分析。
第1组有清晰的囊膜或轻度PCO。第2组出现更严重的PCO或完全混浊。两组之间的差异具有统计学意义（P = 0.04）。
这些初步结果表明，CAPE在抑制有色兔的PCO方面是有效的，并且可能对人类临床应用有益，因为它对正常细胞没有记录在案的有害影响。
