Diyarbakir Training and Research Hospital, Biochemistry Department , Diyarbakir, Turkey.
J Sports Sci Med. 2011 Dec 1;10(4):649-54. eCollection 2011.
In order to understand whether exercise and caffeic acid phenethyl ester (CAPE) has an effect on obesity and weight control, we investigated the effects of CAPE, and exercise on lipid parameters (triglyceride, total cholesterol, HDL-C, LDL-C), and adipokine substances such as leptin and resistin in rats. 40 male rat were randomly assigned into 4 groups. It was determined that CAPE does not have any significant effect on these parameters but that lipid parameters and leptin values in exercise groups decreased considerably, while no significant change occurred in resistin levels. In order to understand whether diet has an effect on exercise, body weights of all animal groups in pre and post-exercise were compared. A significant weight gain was observed (p = 0.005) in all groups. This study concluded that exercise has a considerable effect on leptin and lipid parameters; however, exercise alone was not sufficient for weight control and could be effective in weight control only when accompanied by a restricted diet. Key pointsCaffeic acid phenethyl ester is not effective on weight control, lipid parameters, and adipokine substances such as leptin and resistin.Exercise can be effective in weight control only when accompanied by a restricted diet.
为了了解运动和咖啡酸苯乙酯（CAPE）是否对肥胖和体重控制有影响，我们研究了 CAPE 和运动对大鼠脂质参数（甘油三酯、总胆固醇、HDL-C、LDL-C）和瘦素和抵抗素等脂肪因子的影响。40 只雄性大鼠被随机分为 4 组。结果表明，CAPE 对这些参数没有显著影响，但运动组的脂质参数和瘦素值明显降低，而抵抗素水平没有明显变化。为了了解饮食是否对运动有影响，比较了所有动物组在运动前后的体重。所有组均观察到显著的体重增加（p=0.005）。本研究得出结论，运动对瘦素和脂质参数有显著影响；然而，仅运动本身不足以控制体重，只有在限制饮食的情况下才可能有效控制体重。关键点咖啡酸苯乙酯对体重控制、脂质参数和瘦素和抵抗素等脂肪因子没有作用。运动只有在配合限制饮食的情况下才可能有效控制体重。
