Totan Yüksel, Yağci Ramazan, Erdurmuş Mesut, Bayrak Reyhan, Hepşen Ibrahim Feyzi
Department of Ophthalmology, Medical School, Fatih University, Ankara, Turkey.
Clin Exp Ophthalmol. 2008 Jan-Feb;36(1):62-6. doi: 10.1111/j.1442-9071.2007.01653.x.
To evaluate whether cyclosporin A prevents or reduce posterior capsule opacification after phacoemulsification surgery in rabbit eyes.
Twenty rabbits underwent cataract surgery in their right eyes were randomized into two groups. In group 1, 0.1 mL cyclosporin A (0.5 mg/mL) was given into the capsular bag after phacoemulsification and 0.1 mL cyclosporin A (0.5 mg/mL) was injected subconjunctivally once every 3 days for 1 week. Group 2 served as a control group. The development of posterior capsule opacification was assessed weekly, its density was graded clinically, and the proliferation of lens epithelial cells was evaluated histologically.
On clinical assessment, cyclosporin A was significantly effective in preventing posterior capsule opacification compared with controls (P = 0.0045). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment group, in contrast to multilayer lens epithelial cells proliferation in the control group.
The preliminary results indicate that cyclosporin A is effective in suppressing posterior capsule opacification in rabbits, yet requires further investigation.
评估环孢素A是否能预防或减少兔眼白内障超声乳化手术后的后囊膜混浊。
将20只右眼接受白内障手术的兔子随机分为两组。第1组在超声乳化术后于囊袋内注入0.1 mL环孢素A（0.5 mg/mL），并每隔3天结膜下注射0.1 mL环孢素A（0.5 mg/mL），共1周。第2组作为对照组。每周评估后囊膜混浊的发展情况，临床分级其密度，并通过组织学评估晶状体上皮细胞的增殖情况。
临床评估显示，与对照组相比，环孢素A在预防后囊膜混浊方面具有显著效果（P = 0.0045）。组织学分析表明，治疗组后囊膜的增殖活性显著降低，而对照组出现多层晶状体上皮细胞增殖。
初步结果表明，环孢素A在抑制兔眼后囊膜混浊方面有效，但仍需进一步研究。
