Gould V E, Sommers S C, Terzakis J A
Am J Pathol. 1976 Jul;84(1):25-38.
Eleven endometrial adenoacenthomas were studied ultrastructurally. Special emphasis was placed on patterns of squamous metaplasia and the appearance of the basal laminae. Tonofibrils, irregular keratohyaline, abundant desmosomes, and foci of frank keratinization were observed. However, the granule population was small, with relatively scanty keratohyaline and no definite membrane coating granules. These features resemble squamous metaplasia observed in various epithelia; experimental models utilizing estrogens also resulted in similar changes. This observation appears pertinent in view of the possible etiologic role played by high estrogen levels in the development of human endometrial carcinoma. Most tumor cell clusters were surrounded by a well-defined basal lamina; focal basal lamina reduplication was also observed. These observations suggest a high level of differentiation in respect to synthetic capabilities and cell surface recognition. They correlate well with the relatively favorable prognosis generally observed in endometrial adenoacanthomas. However, these conclusions are tempered by the finding of occasionally absent or defective basal lamine, indicative of partial dedifferentiation of some neoplastic cells.
对11例子宫内膜腺棘皮瘤进行了超微结构研究。特别强调了鳞状化生模式和基膜的外观。观察到张力原纤维、不规则透明角质颗粒、丰富的桥粒和明显的角化灶。然而，颗粒数量较少，透明角质颗粒相对稀少，且无明确的膜被颗粒。这些特征类似于在各种上皮中观察到的鳞状化生；利用雌激素的实验模型也导致了类似的变化。鉴于高雌激素水平在人类子宫内膜癌发生中可能发挥的病因学作用，这一观察结果似乎具有相关性。大多数肿瘤细胞团被明确的基膜包围；还观察到局灶性基膜重复。这些观察结果表明在合成能力和细胞表面识别方面具有高度分化。它们与子宫内膜腺棘皮瘤中通常观察到的相对良好的预后密切相关。然而，偶尔出现的基膜缺失或缺陷这一发现缓和了这些结论，这表明一些肿瘤细胞存在部分去分化。
