Stranahan P L, LaRoe J, McCombs R, Rahim I, Kuhn C W, Pettijohn D E
University of Colorado Cancer Center, Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Oncol Rep. 1998 Jan-Feb;5(1):235-9. doi: 10.3892/or.5.1.235.
An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas, and is a prognostic marker for squamous cell lung carcinomas. All of the tumor specimen evaluated were positive and no expression of Le(a)-Le(x) was detected in derivatives of neural, connective or muscle tissues. These findings indicate that it could be informative to examine the biological significance of Le(a)-Le(x) not only in carcinogenesis but during embryogenesis, as well.
对胆管、胰腺、结肠和胃的腺癌进行了Le(a)-Le(x)表达的免疫组织化学评估，这些腺癌是源自胚胎内胚层的上皮肿瘤的实例。这补充了先前的研究，这些研究表明Lea-Lex存在于非小细胞肺癌、一些非肺癌的细胞表面，并且是肺鳞状细胞癌的预后标志物。所有评估的肿瘤标本均呈阳性，在神经、结缔组织或肌肉组织的衍生物中未检测到Le(a)-Le(x)的表达。这些发现表明，研究Le(a)-Le(x)不仅在致癌过程中而且在胚胎发生过程中的生物学意义可能会提供有价值的信息。
