McDonagh T A, Woodward M, Morrison C E, McMurray J J, Tunstall-Pedoe H, Lowe G D, McColl K E, Dargie H J
Department of Cardiology, Western Infirmary, Glasgow, Scotland, UK.
Eur Heart J. 1997 Aug;18(8):1257-60. doi: 10.1093/oxfordjournals.eurheartj.a015436.
Recent evidence suggests that Helicobacter pylori infection is associated with coronary heart disease. We investigated whether H. Pylori infection is related to prevalent coronary heart disease, in a random sample of 1428 men and women aged 25-74 years.
Coronary heart disease was assessed by questionnaire and electrocardiography (ECG). Standard risk factors for coronary heart disease, fibrinogen concentration and serum concentrations of H. pylori-specific IgG antibody were measured. H. pylori seropositivity increased with age (P < or = 0.001) and was significantly more prevalent in men than women. H. pylori infection was associated with current smoking and a higher systolic blood pressure in men but not in women. There was no significant increase in the odds ratio in those seropositive for H. pylori with regard to any manifestation of coronary heart disease, after adjustment for age, standard cardiovascular risk factors and social class. Likewise, age-adjusted plasma fibrinogen was no higher in seropositives.
Seropositivity to H. pylori is associated with a trend towards a greater prevalence of coronary heart disease. However, that association is likely to be spurious and can be adequately explained by the much stronger association of H. pylori infection with age and social class, both of which are linked with coronary heart disease.
近期证据表明幽门螺杆菌感染与冠心病有关。我们在一个由1428名年龄在25 - 74岁之间的男性和女性组成的随机样本中，调查了幽门螺杆菌感染是否与冠心病的患病率相关。
通过问卷调查和心电图（ECG）评估冠心病。测量冠心病的标准危险因素、纤维蛋白原浓度以及幽门螺杆菌特异性IgG抗体的血清浓度。幽门螺杆菌血清阳性率随年龄增加而升高（P≤0.001），且在男性中显著高于女性。幽门螺杆菌感染与男性当前吸烟及较高的收缩压相关，但与女性无关。在对年龄、标准心血管危险因素和社会阶层进行调整后，幽门螺杆菌血清阳性者在冠心病的任何表现方面，优势比均无显著增加。同样，血清阳性者经年龄调整后的血浆纤维蛋白原也不更高。
幽门螺杆菌血清阳性与冠心病患病率更高的趋势相关。然而，这种关联可能是虚假的，并且可以通过幽门螺杆菌感染与年龄和社会阶层更强的关联得到充分解释，而年龄和社会阶层均与冠心病有关。
