Pellicano R, Mazzarello M G, Morelloni S, Allegri M, Arena V, Ferrari M, Rizzetto M, Ponzetto A
Department of Gastroenterology, Molinette Hospital, Turin, Italy.
Int J Clin Lab Res. 1999;29(4):141-4. doi: 10.1007/s005990050080.
Infectious agents including Helicobacter pylori, have been linked to coronary heart diseases on epidemiological and pathogenetic grounds. Classical risk factors fail to explain all the epidemiological variations of the disease. Our aim was to investigate the association of acute myocardial infarction with Helicobacter pylori infection in a case-control study by comparing a group of male patients with a control group of blood donors matched for sex and age. We investigated the classical cardiovascular risk factors in all patients. We studied 44 consecutive male patients, aged 40-65 years, admitted for acute myocardial infarction to the Coronary Care Unit at Novi Ligure Hospital in northern Italy. Helicobacter pylori infection was assessed by measurement of antibodies (IgG) against Helicobacter pylori in blood. Volunteer blood donors attending Molinette Hospital Blood Bank in Turin, northern Italy served as controls. Among the patients we investigated the presence of hypertension, cholesterol and glucose levels in serum, fibrinogen in plasma, smoking habits, and social class. Helicobacter pylori infection was present in 34 of 44 (77%) patients and in 183 of 310 (59%) controls (P<0.05); the odds ratio was 2.36 (95% confidence interval 1.08-5.31). Classical cardiovascular risk factors did not differ among patients with and without Helicobacter pylori infection. In conclusion, patients with acute myocardial infarction had a significantly higher prevalence of Helicobacter pylori infection than the control population. The classical risk factors for cardiovascular diseases were equally distributed among patients irrespective of their Helicobacter pylori status.
包括幽门螺杆菌在内的感染因子，基于流行病学和发病机制的原因，已被认为与冠心病有关。传统的风险因素无法解释该疾病所有的流行病学差异。我们的目的是通过比较一组男性患者和一组年龄与性别匹配的献血者对照组，在一项病例对照研究中调查急性心肌梗死与幽门螺杆菌感染之间的关联。我们调查了所有患者的传统心血管风险因素。我们研究了44例年龄在40 - 65岁之间、因急性心肌梗死入住意大利北部诺维利古雷医院冠心病监护病房的连续男性患者。通过检测血液中抗幽门螺杆菌抗体（IgG）来评估幽门螺杆菌感染情况。来自意大利北部都灵莫利内特医院血库的志愿献血者作为对照组。在患者中，我们调查了高血压、血清胆固醇和葡萄糖水平、血浆纤维蛋白原、吸烟习惯以及社会阶层的情况。44例患者中有34例（77%）存在幽门螺杆菌感染，310例对照组中有183例（59%）存在感染（P<0.05）；比值比为2.36（95%置信区间1.08 - 5.31）。有无幽门螺杆菌感染的患者之间，传统心血管风险因素并无差异。总之，急性心肌梗死患者幽门螺杆菌感染的患病率显著高于对照组人群。无论幽门螺杆菌感染状态如何，心血管疾病的传统风险因素在患者中分布均匀。
