Patel P, Mendall M A, Carrington D, Strachan D P, Leatham E, Molineaux N, Levy J, Blakeston C, Seymour C A, Camm A J
St George's Hospital Medical School, Tooting, London.
BMJ. 1995 Sep 16;311(7007):711-4. doi: 10.1136/bmj.311.7007.711.
To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors.
Cross sectional study of a population based random sample of men. Coronary heart disease was assessed by electrocardiography, Rose angina questionnaire, and a history of myocardial infarction; serum antibody levels to H pylori and C pneumoniae were measured, risk factor levels determined, and a questionnaire administered.
General practices in Merton, Sutton, and Wandsworth, south London.
388 white south London men aged 50-69.
Evidence of coronary risk factors and infection with H pylori or C pneumoniae.
47 men (12.1%) had electrocardiographic evidence of ischaemia or infarction. 36 (76.6%) and 18 (38.3%) were seropositive for H pylori and C pneumoniae, respectively, compared with 155 (45.5%) and 62 (18.2%) men with normal electrocardiograms. Odds ratios for abnormal electrocardiograms were 3.82 (95% confidence interval 1.60 to 9.10) and 3.06 (1.33 to 7.01) in men seropositive for H pylori and C pneumoniae, respectively, after adjustment for a range of socioeconomic indicators and risk factors for coronary heart disease. Cardiovascular risk factors that were independently associated with seropositivity to H pylori included fibrinogen concentration and total leucocyte count. Seropositivity to C pneumoniae was independently associated with raised fibrinogen and malondialdehyde concentrations.
Both H pylori and C pneumoniae infectins are associated with coronary heart disease. These relations are not explained by a wide range of confounding factors. Possible mechanisms include an increase in risk factor levels due to a low grade chronic inflammatory response.
研究幽门螺杆菌和肺炎衣原体慢性感染的血清学阳性与冠心病及心血管危险因素之间的关系。
基于人群的男性随机抽样横断面研究。通过心电图、罗斯心绞痛问卷和心肌梗死病史评估冠心病；测量幽门螺杆菌和肺炎衣原体的血清抗体水平，确定危险因素水平，并进行问卷调查。
伦敦南部默顿、萨顿和旺兹沃思的全科医疗诊所。
388名年龄在50 - 69岁的伦敦南部白人男性。
冠心病危险因素及幽门螺杆菌或肺炎衣原体感染的证据。
47名男性（12.1%）有心电图显示缺血或梗死的证据。幽门螺杆菌和肺炎衣原体血清学阳性者分别为36名（76.6%）和18名（38.3%），而心电图正常的男性分别为155名（45.5%）和62名（18.2%）。在调整一系列社会经济指标和冠心病危险因素后，幽门螺杆菌和肺炎衣原体血清学阳性男性心电图异常的比值比分别为3.82（95%置信区间1.60至9.10）和3.06（1.33至7.01）。与幽门螺杆菌血清学阳性独立相关的心血管危险因素包括纤维蛋白原浓度和白细胞总数。肺炎衣原体血清学阳性与纤维蛋白原和丙二醛浓度升高独立相关。
幽门螺杆菌和肺炎衣原体感染均与冠心病有关。这些关系不能用多种混杂因素来解释。可能的机制包括低度慢性炎症反应导致危险因素水平增加。
