Schick D G, Canawati H N, Montgomerie J Z
Department of Medicine, Rancho Los Amigos Medical Center, Downey, California 90242, USA.
Diagn Microbiol Infect Dis. 1997 Dec;29(4):233-9. doi: 10.1016/s0732-8893(97)00161-2.
The activities of trovafloxacin and ciprofloxacin against 38 strains of non-beta-lactamase-producing enterococci, resistant to ampicillin, 34 strains susceptible to ampicillin, and 3 vancomycin-resistant enterococci were studied. Trovafloxacin was more active than ciprofloxacin against all the enterococci studied. The ampicillin-resistant strains were more susceptible than the ampicillin-susceptible strains to both agents. The effect of combining trovafloxacin with gentamicin, ampicillin-sulbactam, novobiocin, rifampin, teicoplanin, and vancomycin was determined for 17 strains by the checkerboard method. An additive effect by inhibition was seen with all antibiotics studied. The results by killing varied with the different agents studied. Gentamicin, ampicillin-sulbactam, and novobiocin produced an additive killing effect with trovafloxacin. Reduced killing was seen when rifampin, vancomycin, or teicoplanin were added to trovafloxacin.
研究了曲伐沙星和环丙沙星对38株对氨苄西林耐药的非β-内酰胺酶产生肠球菌、34株对氨苄西林敏感的肠球菌以及3株耐万古霉素肠球菌的活性。在所有研究的肠球菌中，曲伐沙星比环丙沙星活性更强。对两种药物而言，耐氨苄西林菌株比敏感菌株更易被抑制。采用棋盘法测定了曲伐沙星与庆大霉素、氨苄西林-舒巴坦、新生霉素、利福平、替考拉宁和万古霉素联合对17株菌株的作用。在所研究的所有抗生素中均观察到抑制的相加作用。杀菌结果因所研究的不同药物而异。庆大霉素、氨苄西林-舒巴坦和新生霉素与曲伐沙星产生相加杀菌作用。当利福平、万古霉素或替考拉宁与曲伐沙星合用时，杀菌作用减弱。
