Tuohy M, Washington J A
Cleveland Clinic Foundation, Ohio 44195-5140, USA.
Diagn Microbiol Infect Dis. 1997 Dec;29(4):277-80. doi: 10.1016/s0732-8893(97)00140-5.
A total of 68 viridans group streptococci, including 31 Streptococcus sanguis, 12 S. mitis, 3 S. salivarius, and 8 S. milleri from blood, and an additional 14 S. milleri from abscesses and normally sterile sites, were tested against penicillin, amoxicillin, cefazolin, ceftriaxone, meropenem, clindamycin, quinupristin/dalfopristin, rifampin, levofloxacin, ofloxacin, vancomycin, and gentamicin with the microdilution method. The susceptibility rates for S. sanguis were: penicillin, 74%; amoxicillin, 84%; ceftriaxone, 94%; clindamycin, 87%, and vancomycin, 100%. The susceptibility rates for S. mitis were: penicillin, 42%; amoxicillin, 67%; ceftriaxone, 58%; clindamycin, 100%; and vancomycin, 100%. The susceptibility rates for S. milleri were: penicillin, 100%, amoxicillin. 100%; ceftriaxone, 100%, clindamycin, 100%; and vancomycin, 100%. Two of the three isolates of S. salivarius were susceptible to penicillin, amoxicillin, and ceftriaxone; all were susceptible to clindamycin and vancomycin. Levofloxacin, quinupristin/dalfopristin, and rifampin were highly active against all isolates.
总共68株草绿色链球菌，包括31株血链球菌、12株缓症链球菌、3株唾液链球菌和8株来自血液的米勒链球菌，以及另外14株来自脓肿和通常无菌部位的米勒链球菌，采用微量稀释法对青霉素、阿莫西林、头孢唑林、头孢曲松、美罗培南、克林霉素、奎奴普丁/达福普汀、利福平、左氧氟沙星、氧氟沙星、万古霉素和庆大霉素进行了测试。血链球菌的药敏率分别为：青霉素74%；阿莫西林84%；头孢曲松94%；克林霉素87%；万古霉素100%。缓症链球菌的药敏率分别为：青霉素42%；阿莫西林67%；头孢曲松58%；克林霉素100%；万古霉素100%。米勒链球菌的药敏率分别为：青霉素100%，阿莫西林100%；头孢曲松100%，克林霉素100%；万古霉素100%。3株唾液链球菌中有2株对青霉素、阿莫西林和头孢曲松敏感；所有菌株对克林霉素和万古霉素敏感。左氧氟沙星、奎奴普丁/达福普汀和利福平对所有分离株均具有高活性。
