Washington N, Harris M, Mussellwhite A, Spiller R C
Division of Gastroenterology and Department of Surgery, Queen's Medical Centre, Nottingham, United Kingdom.
Am J Clin Nutr. 1998 Feb;67(2):317-21. doi: 10.1093/ajcn/67.2.237.
Psyllium has been reported to inhibit lactulose-induced colonic mass movements and to benefit patients with irritable bowel syndrome, improving both constipation and diarrhea. Our aim was to define how psyllium modified the whole-gut transit of a radiolabeled lactulose-containing test meal by using gamma scintigraphy. Eight subjects participated in a randomized crossover study comparing gastric emptying and small bowel and colonic transit after consumption of 20 mL lactulose three times daily with or without 3.5 g psyllium three times daily. Psyllium significantly delayed gastric emptying: the time to 50% emptying increased from a control value of 69 +/- 9 to 87 +/- 11 min (mean +/- SEM; P < 0.05, n = 8). Small bowel transit was unaltered. However, progression through the colon was delayed with an increase in the percentage of the dose at 24 h in the ascending (control group: 2 +/- 3%, psyllium group: 11 +/- 8%; P < 0.02) and transverse colon (control group: 5 +/- 12%, psyllium group: 21 +/- 14%) with correspondingly less in the descending colon. Although the time for 50% of the isotope to reach the colon was not significantly different with psyllium, psyllium significantly delayed the rise in breath-hydrogen concentrations, which reached 50% of their peak at 217 +/- 34 min compared with control values of 155 +/- 27 min (P < 0.05). Psyllium delays gastric emptying, probably by increasing meal viscosity, and reduces the acceleration of colon transit, possibly by delaying the production of gaseous fermentation products.
据报道，车前草可抑制乳果糖诱导的结肠集团运动，并对肠易激综合征患者有益，可改善便秘和腹泻症状。我们的目的是通过γ闪烁扫描术确定车前草如何改变含放射性标记乳果糖的试验餐的全肠道转运。八名受试者参与了一项随机交叉研究，比较每日三次服用20 mL乳果糖，或每日三次服用20 mL乳果糖加3.5 g车前草后胃排空、小肠和结肠的转运情况。车前草显著延迟胃排空：50%排空时间从对照组的69±9分钟增加到87±11分钟（平均值±标准误；P<0.05，n=8）。小肠转运未改变。然而，结肠推进延迟，升结肠（对照组：2±3%，车前草组：11±8%；P<0.02）和横结肠（对照组：5±12%，车前草组：21±14%）中24小时剂量百分比增加，而降结肠中相应减少。尽管车前草组同位素到达结肠50%的时间与对照组无显著差异，但车前草显著延迟了呼气氢浓度的上升，其达到峰值的50%的时间为217±34分钟，而对照组为155±27分钟（P<0.05）。车前草可能通过增加餐食粘度来延迟胃排空，并可能通过延迟气态发酵产物的产生来减缓结肠转运的加速。
