Gα蛋白ODR-3介导嗅觉和伤害感受功能，并控制秀丽隐杆线虫嗅觉神经元中的纤毛形态发生。

The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons.

作者信息

Roayaie K, Crump J G, Sagasti A, Bargmann C I

机构信息

Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143, USA.

出版信息

Neuron. 1998 Jan;20(1):55-67. doi: 10.1016/s0896-6273(00)80434-1.

DOI:10.1016/s0896-6273(00)80434-1

PMID:9459442

Abstract

The Gi/Go-like G alpha protein ODR-3 is strongly and selectively implicated in the function of C. elegans olfactory and nociceptive neurons. Either loss of odr-3 function or overexpression of odr-3 causes severe olfactory defects, and odr-3 function is essential in the ASH neurons that sense noxious chemical and mechanical stimuli. In the nociceptive neurons, ODR-3 may interact with OSM-9, a channel similar to the mammalian capsaicin receptor implicated in pain sensation; in AWC olfactory neurons, ODR-3 may interact with another signal transduction pathway. ODR-3 exhibits an unexpected ability to regulate morphogenesis of the olfactory cilia. In odr-3 null mutants, the fan-like AWC cilia take on a filamentous morphology like normal AWA cilia, whereas ODR-3 overexpression in AWA transforms its filamentous cilia into a fan-like morphology.

摘要

类似Gi/Go的Gα蛋白ODR-3与秀丽隐杆线虫嗅觉和伤害感受神经元的功能密切且选择性相关。odr-3功能丧失或odr-3过表达都会导致严重的嗅觉缺陷，并且odr-3功能在感知有害化学和机械刺激的ASH神经元中至关重要。在伤害感受神经元中，ODR-3可能与OSM-9相互作用，OSM-9是一种类似于参与痛觉的哺乳动物辣椒素受体的通道；在AWC嗅觉神经元中，ODR-3可能与另一种信号转导途径相互作用。ODR-3展现出调控嗅觉纤毛形态发生的意外能力。在odr-3基因敲除突变体中，扇形的AWC纤毛呈现出与正常AWA纤毛相似的丝状形态，而在AWA中过表达ODR-3则会将其丝状纤毛转变为扇形形态。