Vega Ashley, Chua Alexis, Tran Annabelle, Seader Amber, Chang Emily, Ayala Liz, Torres Adriana, Pontrelli Gianina, Harris Gareth
California State University, Channel Islands, Camarillo, California, United States.
Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, United States.
MicroPubl Biol. 2024 Oct 18;2024. doi: 10.17912/micropub.biology.001242. eCollection 2024.
The coffee industry reaches over 80 billion US dollars in revenue partially due to the numerous chemicals that allow for coffee's highly attractive aroma and overall flavor. Many people integrate coffee into their everyday routine; therefore, understanding the attraction to coffee can facilitate, 1) the characterization of its attractive nature, and, 2) allow further understanding of how humans interpret taste and smell on a molecular and cellular level, from initial sensation to higher processing of these complex neural signals. We report that the model worm, , can smell and perform strong attraction behavior using chemotaxis towards various types of coffee odors. In this study, we show that the nematode is strongly attracted to various forms of coffee. We have also identified neuronal molecules that mediate this sensory-dependent behavior. Overall, we provide a platform to more thoroughly dissect the mechanisms and neuronal circuits that mediate odor-guided behavior to a complex human-sensed stimulus.
咖啡产业的收入超过800亿美元，部分原因是众多化学物质赋予了咖啡极具吸引力的香气和整体风味。许多人将咖啡融入日常生活；因此，了解人们对咖啡的喜爱有助于：1） 表征其吸引人的特性；2） 进一步理解人类如何在分子和细胞水平上诠释味觉和嗅觉，从最初的感知到对这些复杂神经信号的高级处理。我们报告称，模式生物线虫可以通过趋化作用嗅到各种咖啡气味，并表现出强烈的吸引行为。在本研究中，我们表明线虫对各种形式的咖啡有强烈的吸引力。我们还鉴定出了介导这种感官依赖行为的神经元分子。总体而言，我们提供了一个平台，以便更全面地剖析介导对复杂人类感知刺激的气味引导行为的机制和神经回路。
