Kessler M, Maurus Y, Köstlin R
Chirurgischen Tierklinik, Universität München.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 1997 Nov;25(6):651-6.
This study describes clinical aspects, treatment, and survival times of 52 dogs with hemangiosarcoma of the spleen, presented at the Department of Veterinary Surgery, University of Munich, Germany. Depending on the dissemination of the disease the dogs were assigned to three clinical stages: 10 dogs were in stage I (tumor confined to the spleen without metastasis), 18 in stage II (tumor confined to the spleen or ruptured, with or without lymph node involvement but without distant metastasis) and 24 in stage III (with distant metastasis). Dogs in stage I displayed mild and nonspecific symptoms. In stage II and II, half of the patients were presented in shock or collapse after an acute rupture of the tumor. Sonographic examination was found superior in diagnosing splenic neoplasia when compared to radiography. Pronounced laboratory abnormalities were present mainly in patients in stages II or III with anemia, leucocytosis, thrombocytopenia and prolonged bleeding times predominating. Survival times following splenectomy were very variable. The median survival time was 100 days. Because of the high standard deviaton there was no statistically significant difference in survival times between animals of different stages.
本研究描述了德国慕尼黑大学兽医外科收治的52只患有脾脏血管肉瘤的犬的临床症状、治疗方法和存活时间。根据疾病的扩散情况,这些犬被分为三个临床阶段:10只处于I期(肿瘤局限于脾脏,无转移),18只处于II期(肿瘤局限于脾脏或破裂,有或无淋巴结受累,但无远处转移),24只处于III期(有远处转移)。I期的犬表现出轻微和非特异性症状。在II期和III期,一半的患者在肿瘤急性破裂后出现休克或虚脱。与放射成像相比,超声检查在诊断脾脏肿瘤方面更具优势。明显的实验室异常主要出现在II期或III期的患者中,以贫血、白细胞增多、血小板减少和出血时间延长为主。脾切除术后的存活时间差异很大。中位存活时间为100天。由于标准差较高,不同阶段动物的存活时间在统计学上没有显著差异。